Biopharmaceuticals(CDMO business) Research and development
We offer services to support early-stage research in the development of biopharmaceuticals, from cell development to filling of active pharmaceutical ingredients for use in non-clinical studies and a full range of analyses.
We conduct testing in accordance with Standard of Reliability of Application Data.
We can also conduct design space studies in QbD.
Culturing and purification
We have a 200 L bioreactor, and we can accommodate culturing and purification processes from micro-plate scale to pilot scale.
|Incubators (2 units)||For Screening of cell lines and optimization of medium|
|CO² incubators (3 units)|
|Micro-bioreactor||Working volume:15 mL, 24 channels
For study of cultivation parameters
|Jar fermentor||Working volume:3 L (3 units) and 12 L (2 units)
For study of cultivation parameters and scale-up factor
|Single-use bioreactor||Working volume:200 L
For study of scale-up
|Perfusion bioreactor||For high density cell cultivation and study of continuous manufacturing|
|Refrigerated continuous centrifuge||For removal of cells from culture medium|
|Chromatography systems||small-scale (3 units) and pilot-scale (1 unit)
For study and optimization of purification parameters
|Continuous chromatography||For study of continuous chromatography|
|Tangential flow filtration||For buffer-changing, concentrated and removal of virus|
|Freeze-Drying system||For study of Freeze-Drying conditions|
We can perform protein analysis (molecular interaction, thermal stability, etc.) and gene analysis.
For protein analysis by chromatography.
|Microplate reader||Absorbance, fluorescence, and luminescence measurement
For expression analysis by ELISA and cell-based assay.
|Molecular interaction analyzer||For analysis of protein-protein molecular interactions|
For analysis of protein thermostability
|Particle size analyzer||For analysis of protein particle size|
|qPCR||For quantification of DNA concentration|
|DNA sequencer||For identification of DNA sequences|
Allows us to analyze protein characteristics such as physical and chemical properties, purity, and impurities.
Types of analyses we can perform (partial list)
|Type of analysis||Description|
|Peptide mapping||Analysis of amino acid sequences and modification using peptide measurement|
|Disulfide mapping||Analysis of disulfide bond locations|
|Intact protein||Precise analysis of molecular weight|
|C-terminal amino acid analysis||Identification of C-terminal peptides using stable oxygen isotopes|
|Sugar chain analysis
|Fluorometric and mass spectrometric analysis of glycosylated proteins|
|Purity analysis||Evaluation of protein purity using SDS gel electrophoresis|
|Isoelectric focusing||Measurement of isoelectric point by means of chemical mobilization|
|Oligosaccharide analysis||Analysis of oligosaccharides using fluorescence labeling|
|Monosaccharide analysis||Analysis of the structure of monosaccharaides using fluorescence labeling|